Western Diet Induces Paneth Cell Defects through Microbiome Alterations and Farnesoid X Receptor and Type I Interferon Activation

Intestinal Paneth cells modulate innate immunity and infection. In Crohn’s disease, genetic mutations together with environmental triggers can disable Paneth cell function. Here, we find that a Western diet (WD) similarly leads to Paneth cell dysfunction through mechanisms dependent on the microbiom...

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發表在:Cell Host Microbe
Main Authors: Liu, Ta-Chiang, Kern, Justin T., Jain, Umang, Sonnek, Naomi M., Xiong, Shanshan, Simpson, Katherine F., VanDussen, Kelli L., Winkler, Emma S., Haritunians, Talin, Malique, Atika, Lu, Qiuhe, Sasaki, Yo, Storer, Chad, Diamond, Michael S., Head, Richard D., McGovern, Dermot P.B., Stappenbeck, Thaddeus S.
格式: Artigo
語言:Inglês
出版: 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8192497/
https://ncbi.nlm.nih.gov/pubmed/34010595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2021.04.004
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