Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase

The prototypical second messenger cAMP regulates a wide variety of physiological processes. It can simultaneously mediate diverse functions by acting locally within independently-regulated microdomains. In mammalian cells, two types of adenylyl cyclase generate cAMP; G protein regulated transmembran...

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Veröffentlicht in:Nat Chem Biol
Hauptverfasser: Ramos-Espiritu, Lavoisier, Kleinboelting, Silke, Navarrete, Felipe A., Alvau, Antonio, Visconti, Pablo E., Valsecchi, Federica, Starkov, Anatoly, Manfredi, Giovanni, Buck, Hannes, Adura, Carolina, Zippin, Jonathan H., van den Heuvel, Joop, Glickman, J. Fraser, Steegborn, Clemens, Levin, Lonny R., Buck, Jochen
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030147/
https://ncbi.nlm.nih.gov/pubmed/27547922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2151
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