Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate

cAMP is an evolutionary conserved, prototypic second messenger regulating numerous cellular functions. In mammals, cAMP is synthesized by one of 10 homologous adenylyl cyclases (ACs): nine transmembrane enzymes and one soluble AC (sAC). Among these, only sAC is directly activated by bicarbonate (HCO...

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Bibliografiska uppgifter
Huvudupphovsmän: Kleinboelting, Silke, Diaz, Ana, Moniot, Sebastien, van den Heuvel, Joop, Weyand, Michael, Levin, Lonny R., Buck, Jochen, Steegborn, Clemens
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2014
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956179/
https://ncbi.nlm.nih.gov/pubmed/24567411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322778111
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