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Expression, purification, crystallization and preliminary X-ray diffraction analysis of a mammalian type 10 adenylyl cyclase

The second messenger cAMP is synthesized in mammals by ten differently regulated adenylyl cyclases (AC1–10). These ACs are grouped into nucleotidyl cyclase class III based on homologies in their catalytic domains. The catalytic domain of AC10 is unique, however, in being activated through direct int...

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Detalhes bibliográficos
Main Authors: Kleinboelting, Silke, van den Heuvel, Joop, Kambach, Christian, Weyand, Michael, Leipelt, Martina, Steegborn, Clemens
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976064/
https://ncbi.nlm.nih.gov/pubmed/24699740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X14004014
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