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Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase
The prototypical second messenger cAMP regulates a wide variety of physiological processes. It can simultaneously mediate diverse functions by acting locally within independently-regulated microdomains. In mammalian cells, two types of adenylyl cyclase generate cAMP; G protein regulated transmembran...
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Publicado no: | Nat Chem Biol |
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Main Authors: | , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5030147/ https://ncbi.nlm.nih.gov/pubmed/27547922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2151 |
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