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Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase

The prototypical second messenger cAMP regulates a wide variety of physiological processes. It can simultaneously mediate diverse functions by acting locally within independently-regulated microdomains. In mammalian cells, two types of adenylyl cyclase generate cAMP; G protein regulated transmembran...

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Bibliografski detalji
Izdano u:Nat Chem Biol
Glavni autori: Ramos-Espiritu, Lavoisier, Kleinboelting, Silke, Navarrete, Felipe A., Alvau, Antonio, Visconti, Pablo E., Valsecchi, Federica, Starkov, Anatoly, Manfredi, Giovanni, Buck, Hannes, Adura, Carolina, Zippin, Jonathan H., van den Heuvel, Joop, Glickman, J. Fraser, Steegborn, Clemens, Levin, Lonny R., Buck, Jochen
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030147/
https://ncbi.nlm.nih.gov/pubmed/27547922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2151
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