Application of physiologically based pharmacokinetic modeling in predicting drug–drug interactions for sarpogrelate hydrochloride in humans

BACKGROUND: Evaluating the potential risk of metabolic drug–drug interactions (DDIs) is clinically important. OBJECTIVE: To develop a physiologically based pharmacokinetic (PBPK) model for sarpogrelate hydrochloride and its active metabolite, (R,S)-1-{2-[2-(3-methoxyphenyl)ethyl]-phenoxy}-3-(dimethy...

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Bibliografiske detaljer
Udgivet i:Drug Des Devel Ther
Main Authors: Min, Jee Sun, Kim, Doyun, Park, Jung Bae, Heo, Hyunjin, Bae, Soo Hyeon, Seo, Jae Hong, Oh, Euichaul, Bae, Soo Kyung
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2016
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5028085/
https://ncbi.nlm.nih.gov/pubmed/27695293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S109141
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