Physiologically-based pharmacokinetic predictions of intestinal BCRP-mediated drug interactions of rosuvastatin in Koreans

It was recently reported that the C(max) and AUC of rosuvastatin increases when it is coadministered with telmisartan and cyclosporine. Rosuvastatin is known to be a substrate of OATP1B1, OATP1B3, NTCP, and BCRP transporters. The aim of this study was to explore the mechanism of the interactions bet...

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Detalhes bibliográficos
Publicado no:Korean J Physiol Pharmacol
Main Authors: Bae, Soo Hyeon, Park, Wan-Su, Han, Seunghoon, Park, Gab-jin, Lee, Jongtae, Hong, Taegon, Jeon, Sangil, Yim, Dong-Seok
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Physiological Society and The Korean Society of Pharmacology 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928345/
https://ncbi.nlm.nih.gov/pubmed/29719454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2018.22.3.321
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