Physiologically-based pharmacokinetic predictions of intestinal BCRP-mediated drug interactions of rosuvastatin in Koreans

It was recently reported that the C(max) and AUC of rosuvastatin increases when it is coadministered with telmisartan and cyclosporine. Rosuvastatin is known to be a substrate of OATP1B1, OATP1B3, NTCP, and BCRP transporters. The aim of this study was to explore the mechanism of the interactions bet...

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Bibliografiska uppgifter
I publikationen:Korean J Physiol Pharmacol
Huvudupphovsmän: Bae, Soo Hyeon, Park, Wan-Su, Han, Seunghoon, Park, Gab-jin, Lee, Jongtae, Hong, Taegon, Jeon, Sangil, Yim, Dong-Seok
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Korean Physiological Society and The Korean Society of Pharmacology 2018
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928345/
https://ncbi.nlm.nih.gov/pubmed/29719454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2018.22.3.321
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