Physiologically-based pharmacokinetic predictions of intestinal BCRP-mediated drug interactions of rosuvastatin in Koreans

It was recently reported that the C(max) and AUC of rosuvastatin increases when it is coadministered with telmisartan and cyclosporine. Rosuvastatin is known to be a substrate of OATP1B1, OATP1B3, NTCP, and BCRP transporters. The aim of this study was to explore the mechanism of the interactions bet...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Korean J Physiol Pharmacol
Prif Awduron: Bae, Soo Hyeon, Park, Wan-Su, Han, Seunghoon, Park, Gab-jin, Lee, Jongtae, Hong, Taegon, Jeon, Sangil, Yim, Dong-Seok
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Korean Physiological Society and The Korean Society of Pharmacology 2018
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928345/
https://ncbi.nlm.nih.gov/pubmed/29719454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2018.22.3.321
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