Physiologically-based pharmacokinetic predictions of intestinal BCRP-mediated drug interactions of rosuvastatin in Koreans

It was recently reported that the C(max) and AUC of rosuvastatin increases when it is coadministered with telmisartan and cyclosporine. Rosuvastatin is known to be a substrate of OATP1B1, OATP1B3, NTCP, and BCRP transporters. The aim of this study was to explore the mechanism of the interactions bet...

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Опубликовано в: :Korean J Physiol Pharmacol
Главные авторы: Bae, Soo Hyeon, Park, Wan-Su, Han, Seunghoon, Park, Gab-jin, Lee, Jongtae, Hong, Taegon, Jeon, Sangil, Yim, Dong-Seok
Формат: Artigo
Язык:Inglês
Опубликовано: The Korean Physiological Society and The Korean Society of Pharmacology 2018
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928345/
https://ncbi.nlm.nih.gov/pubmed/29719454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2018.22.3.321
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