Metabolic Drug-Drug Interaction Potential of Macrolactin A and 7-O-Succinyl Macrolactin A Assessed by Evaluating Cytochrome P450 Inhibition and Induction and UDP-Glucuronosyltransferase Inhibition In Vitro

Macrolactin A (MA) and 7-O-succinyl macrolactin A (SMA), polyene macrolides containing a 24-membered lactone ring, show antibiotic effects superior to those of teicoplanin against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus. MA and SMA are currently being evaluat...

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Bibliographische Detailangaben
Hauptverfasser: Bae, Soo Hyeon, Kwon, Min Jo, Park, Jung Bae, Kim, Doyun, Kim, Dong-Hee, Kang, Jae-Seon, Kim, Chun-Gyu, Oh, Euichaul, Bae, Soo Kyung
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135859/
https://ncbi.nlm.nih.gov/pubmed/24890600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00018-14
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