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In Vitro Metabolism of Montelukast by Cytochrome P450s and UDP-Glucuronosyltransferases
Montelukast has been recommended as a selective in vitro and in vivo probe of cytochrome P450 (P450) CYP2C8 activity, but its selectivity toward this enzyme remains unclear. We performed detailed characterization of montelukast metabolism in vitro using human liver microsomes (HLMs), expressed P450s...
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| Publicado no: | Drug Metab Dispos |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4658491/ https://ncbi.nlm.nih.gov/pubmed/26374173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.065763 |
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