Assessing Cytochrome P450 and UDP-Glucuronosyltransferase Contributions to Warfarin Metabolism in Humans

As a step toward exploring a targeted metabolomics approach to personalized warfarin (Coumadin) therapy, we developed a liquid chromatography–tandem mass spectrometry (LC-MS/MS) method capable of quantifying specific enantiomeric (R and S) contributions of warfarin (WAR) and the corresponding hydrox...

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Detalhes bibliográficos
Main Authors: Miller, Grover P., Jones, Drew R., Sullivan, Shane Z., Mazur, Anna, Owen, Suzanne N., Mitchell, Neil C., Radominska-Pandya, Anna, Moran, Jeffery H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819755/
https://ncbi.nlm.nih.gov/pubmed/19408964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900031z
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