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In Vitro Cytochrome P450-Mediated Metabolism of Exemestane
Exemestane is a potent and irreversible steroidal aromatase inhibitor drug used for the treatment of estrogen receptor-positive breast cancer. Our aim was to identify and assess the contribution of the specific cytochromes P450 (P450s) responsible for exemestane primary in vitro metabolism. With the...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3014267/ https://ncbi.nlm.nih.gov/pubmed/20876785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.032276 |
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