Improved oral absorption of cilostazol via sulfonate salt formation with mesylate and besylate

OBJECTIVE: Cilostazol is a Biopharmaceutical Classification System class II drug with low solubility and high permeability, so its oral absorption is variable and incomplete. The aim of this study was to prepare two sulfonate salts of cilostazol to increase the dissolution and hence the oral bioavai...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Drug Des Devel Ther
Asıl Yazarlar: Seo, Jae Hong, Park, Jung Bae, Choi, Woong-Kee, Park, Sunhwa, Sung, Yun Jin, Oh, Euichaul, Bae, Soo Kyung
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Dove Medical Press 2015
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524531/
https://ncbi.nlm.nih.gov/pubmed/26251575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S87687
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