Improved oral absorption of cilostazol via sulfonate salt formation with mesylate and besylate

OBJECTIVE: Cilostazol is a Biopharmaceutical Classification System class II drug with low solubility and high permeability, so its oral absorption is variable and incomplete. The aim of this study was to prepare two sulfonate salts of cilostazol to increase the dissolution and hence the oral bioavai...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Drug Des Devel Ther
Главные авторы: Seo, Jae Hong, Park, Jung Bae, Choi, Woong-Kee, Park, Sunhwa, Sung, Yun Jin, Oh, Euichaul, Bae, Soo Kyung
Формат: Artigo
Язык:Inglês
Опубликовано: Dove Medical Press 2015
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524531/
https://ncbi.nlm.nih.gov/pubmed/26251575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S87687
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы