Improved oral absorption of cilostazol via sulfonate salt formation with mesylate and besylate

OBJECTIVE: Cilostazol is a Biopharmaceutical Classification System class II drug with low solubility and high permeability, so its oral absorption is variable and incomplete. The aim of this study was to prepare two sulfonate salts of cilostazol to increase the dissolution and hence the oral bioavai...

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Détails bibliographiques
Publié dans:Drug Des Devel Ther
Auteurs principaux: Seo, Jae Hong, Park, Jung Bae, Choi, Woong-Kee, Park, Sunhwa, Sung, Yun Jin, Oh, Euichaul, Bae, Soo Kyung
Format: Artigo
Langue:Inglês
Publié: Dove Medical Press 2015
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524531/
https://ncbi.nlm.nih.gov/pubmed/26251575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S87687
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