Improved oral absorption of cilostazol via sulfonate salt formation with mesylate and besylate

OBJECTIVE: Cilostazol is a Biopharmaceutical Classification System class II drug with low solubility and high permeability, so its oral absorption is variable and incomplete. The aim of this study was to prepare two sulfonate salts of cilostazol to increase the dissolution and hence the oral bioavai...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Seo, Jae Hong, Park, Jung Bae, Choi, Woong-Kee, Park, Sunhwa, Sung, Yun Jin, Oh, Euichaul, Bae, Soo Kyung
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524531/
https://ncbi.nlm.nih.gov/pubmed/26251575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S87687
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