Reg4(+) deep crypt secretory cells function as epithelial niche for Lgr5(+) stem cells in colon

Leucine-rich repeat-containing G-protein coupled receptor 5-positive (Lgr5(+)) stem cells reside at crypt bottoms of the small and large intestine. Small intestinal Paneth cells supply Wnt3, EGF, and Notch signals to neighboring Lgr5(+) stem cells. Whereas the colon lacks Paneth cells, deep crypt se...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sasaki, Nobuo, Sachs, Norman, Wiebrands, Kay, Ellenbroek, Saskia I. J., Fumagalli, Arianna, Lyubimova, Anna, Begthel, Harry, van den Born, Maaike, van Es, Johan H., Karthaus, Wouter R., Li, Vivian S. W., López-Iglesias, Carmen, Peters, Peter J., van Rheenen, Jacco, van Oudenaarden, Alexander, Clevers, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027439/
https://ncbi.nlm.nih.gov/pubmed/27573849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607327113
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