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Identification and Structural Characterization of Three New Metabolites of Bupropion in Humans

[Image: see text] Bupropion is a widely used antidepressant and the recommended CYP2B6 probe drug. However, current understanding of bupropion elimination pathways is limited. Bupropion has three active circulating metabolites, OH-bupropion, threohydrobupropion, and erythrohydrobupropion, but togeth...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Sager, Jennifer E., Choiniere, John R., Chang, Justine, Stephenson-Famy, Alyssa, Nelson, Wendel L., Isoherranen, Nina
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026406/
https://ncbi.nlm.nih.gov/pubmed/27660681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00189
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