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Stereoselective Metabolism of Bupropion to OH-bupropion, Threohydrobupropion, Erythrohydrobupropion, and 4′-OH-bupropion in vitro

Bupropion is a widely used antidepressant, smoking cessation aid, and weight-loss therapy. It is administered as a racemic mixture, but the pharmacokinetics and activity of bupropion are stereoselective. The activity and side effects of bupropion are attributed to bupropion and its metabolites S,S-...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Sager, Jennifer E., Price, Lauren S. L., Isoherranen, Nina
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034696/
https://ncbi.nlm.nih.gov/pubmed/27495292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.072363
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