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Development and validation of a high-throughput stereoselective LC-MS/MS assay for bupropion, hydroxybupropion, erythrohydrobupropion, and threohydrobupropion in human plasma

A stereoselective analytical method was developed and validated for the quantification of bupropion, and principle metabolites hydroxybupropion, erythrohydrobupropion and threohydrobupropion in human plasma. Separation of individual enantiomers (R)-bupropion, (S)-bupropion, (R,R)-hydroxybupropion, (...

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Detalles Bibliográficos
Publicado en:J Chromatogr B Analyt Technol Biomed Life Sci
Main Authors: Teitelbaum, Aaron M., Flaker, Alicia M., Kharasch, Evan D.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4831137/
https://ncbi.nlm.nih.gov/pubmed/26963497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2016.02.032
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