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Stereoselective method to quantify bupropion and its three major metabolites, hydroxybupropion, erythro-dihydrobupropion, and threo-dihydrobupropion using HPLC-MS/MS

Bupropion metabolites formed via oxidation and reduction exhibit pharmacological activity, but little is known regarding their stereoselective disposition. A novel stereoselective liquid chromatography–tandem mass spectrometry (LC-MS/MS) method was developed to separate and quantify enantiomers of b...

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Detalhes bibliográficos
Publicado no:J Chromatogr B Analyt Technol Biomed Life Sci
Main Authors: Masters, Andrea R., McCoy, Michael, Jones, David R., Desta, Zeruesenay
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866593/
https://ncbi.nlm.nih.gov/pubmed/26946423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2016.02.018
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