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Stereoselective method to quantify bupropion and its three major metabolites, hydroxybupropion, erythro-dihydrobupropion, and threo-dihydrobupropion using HPLC-MS/MS
Bupropion metabolites formed via oxidation and reduction exhibit pharmacological activity, but little is known regarding their stereoselective disposition. A novel stereoselective liquid chromatography–tandem mass spectrometry (LC-MS/MS) method was developed to separate and quantify enantiomers of b...
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Publicado no: | J Chromatogr B Analyt Technol Biomed Life Sci |
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Main Authors: | , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4866593/ https://ncbi.nlm.nih.gov/pubmed/26946423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2016.02.018 |
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