Transdermal delivery of bupropion and its active metabolite, hydroxybupropion: a prodrug strategy as an alternative approach

This investigation includes an evaluation of the percutaneous absorption of bupropion (BUP) and hydroxybupropion (BUPOH) in vitro and in vivo. In addition, a carbamate prodrug of BUPOH (But-BUPOH) was evaluated in vitro. In vitro diffusion studies were conducted in a flow-through diffusion cell syst...

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Detalhes bibliográficos
Main Authors: Kiptoo, Paul K., Paudel, Kalpana S., Hammell, Dana C., Pinninti, Raghotham Reddy, Chen, Jianhong, Crooks, Peter A., Stinchcomb, Audra L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612091/
https://ncbi.nlm.nih.gov/pubmed/18623203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21463
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