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Transdermal delivery of naltrexol and skin permeability lifetime after microneedle treatment in hairless guinea pigs
Controlled-release delivery of 6-β-naltrexol (NTXOL), the major active metabolite of naltrexone, via a transdermal patch is desirable for treatment of alcoholism. Unfortunately, NTXOL does not diffuse across skin at a therapeutic rate. Therefore, the focus of this study was to evaluate microneedle (...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2862091/ https://ncbi.nlm.nih.gov/pubmed/20166200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.22083 |
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