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Flux across microneedle-treated skin is increased by increasing charge of naltrexone and naltrexol in vitro
PURPOSE: The purpose of this investigation was to evaluate the in vitro microneedle (MN) enhanced percutaneous absorption of naltrexone hydrochloride salt (NTX·HCl) compared to naltrexone base (NTX) in hairless guinea pig skin (GP) and human abdominal skin. In a second set of experiments, permeabili...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2757057/ https://ncbi.nlm.nih.gov/pubmed/18449628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-008-9578-3 |
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