IN VITRO PERMEATION OF A PEGYLATED NALTREXONE PRODRUG ACROSS MICRONEEDLE-TREATED SKIN

Microneedles (MN) are a useful tool for increasing skin permeability to xenobiotics. Previous research showed marked improvement in the percutaneous flux of naltrexone (NTX) hydrochloride by the use of MN skin pretreatment alone; however, for better therapeutic effect, further enhancement is desired...

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Autori principali: Milewski, Mikolaj, Yerramreddy, Thirupathi Reddy, Ghosh, Priyanka, Crooks, Peter A., Stinchcomb, Audra L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916235/
https://ncbi.nlm.nih.gov/pubmed/20678989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2010.05.034
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