HUMAN SKIN PERMEATION OF 3-O-ALKYL CARBAMATE PRODRUGS OF NALTREXONE

N-Monoalkyl and N,N-dialkyl carbamate prodrugs of naltrexone (NTX), an opioid antagonist, were synthesized and their in vitro permeation across human skin was determined. Relevant physicochemical properties were also determined. Most prodrugs exhibited lower melting points, lower aqueous solubilitie...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Vaddi, Haranath K., Banks, Stan L., Chen, Jianhong, Hammell, Dana C., Crooks, Peter A., Stinchcomb, Audra L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764244/
https://ncbi.nlm.nih.gov/pubmed/18972573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21594
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky