HUMAN SKIN PERMEATION OF 3-O-ALKYL CARBAMATE PRODRUGS OF NALTREXONE

N-Monoalkyl and N,N-dialkyl carbamate prodrugs of naltrexone (NTX), an opioid antagonist, were synthesized and their in vitro permeation across human skin was determined. Relevant physicochemical properties were also determined. Most prodrugs exhibited lower melting points, lower aqueous solubilitie...

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Main Authors: Vaddi, Haranath K., Banks, Stan L., Chen, Jianhong, Hammell, Dana C., Crooks, Peter A., Stinchcomb, Audra L.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764244/
https://ncbi.nlm.nih.gov/pubmed/18972573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21594
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