Transdermal delivery of naltrexol and skin permeability lifetime after microneedle treatment in hairless guinea pigs

Controlled-release delivery of 6-β-naltrexol (NTXOL), the major active metabolite of naltrexone, via a transdermal patch is desirable for treatment of alcoholism. Unfortunately, NTXOL does not diffuse across skin at a therapeutic rate. Therefore, the focus of this study was to evaluate microneedle (...

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Bibliografiske detaljer
Main Authors: Banks, Stan L., Pinninti, Raghotham R., Gill, Harvinder S., Paudel, Kalpana S., Crooks, Peter A., Brogden, Nicole K., Prausnitz, Mark R., Stinchcomb, Audra L.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862091/
https://ncbi.nlm.nih.gov/pubmed/20166200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.22083
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