Antitumor effect of antitissue factor antibody‐MMAE conjugate in human pancreatic tumor xenografts

Tissue factor (TF) triggers the extrinsic blood coagulation cascade and is highly expressed in various types of cancer. In this study, we investigated the antitumor effect of an antibody–drug conjugate (ADC) consisting of an anti‐TF monoclonal antibody and monomethyl auristatin E (MMAE). MMAE was co...

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Bibliografiska uppgifter
I publikationen:Int J Cancer
Huvudupphovsmän: Koga, Yoshikatsu, Manabe, Shino, Aihara, Yoshiyuki, Sato, Ryuta, Tsumura, Ryo, Iwafuji, Hikaru, Furuya, Fumiaki, Fuchigami, Hirobumi, Fujiwara, Yuki, Hisada, Yohei, Yamamoto, Yoshiyuki, Yasunaga, Masahiro, Matsumura, Yasuhiro
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2015
Ämnen:
Cancer Therapy
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024081/
https://ncbi.nlm.nih.gov/pubmed/25704403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.29492
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