Antitumor effect of antitissue factor antibody‐MMAE conjugate in human pancreatic tumor xenografts

Tissue factor (TF) triggers the extrinsic blood coagulation cascade and is highly expressed in various types of cancer. In this study, we investigated the antitumor effect of an antibody–drug conjugate (ADC) consisting of an anti‐TF monoclonal antibody and monomethyl auristatin E (MMAE). MMAE was co...

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Dades bibliogràfiques
Publicat a:Int J Cancer
Autors principals: Koga, Yoshikatsu, Manabe, Shino, Aihara, Yoshiyuki, Sato, Ryuta, Tsumura, Ryo, Iwafuji, Hikaru, Furuya, Fumiaki, Fuchigami, Hirobumi, Fujiwara, Yuki, Hisada, Yohei, Yamamoto, Yoshiyuki, Yasunaga, Masahiro, Matsumura, Yasuhiro
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2015
Matèries:
Cancer Therapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024081/
https://ncbi.nlm.nih.gov/pubmed/25704403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.29492
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