Antitumor effect of antitissue factor antibody‐MMAE conjugate in human pancreatic tumor xenografts

Tissue factor (TF) triggers the extrinsic blood coagulation cascade and is highly expressed in various types of cancer. In this study, we investigated the antitumor effect of an antibody–drug conjugate (ADC) consisting of an anti‐TF monoclonal antibody and monomethyl auristatin E (MMAE). MMAE was co...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Int J Cancer
Päätekijät: Koga, Yoshikatsu, Manabe, Shino, Aihara, Yoshiyuki, Sato, Ryuta, Tsumura, Ryo, Iwafuji, Hikaru, Furuya, Fumiaki, Fuchigami, Hirobumi, Fujiwara, Yuki, Hisada, Yohei, Yamamoto, Yoshiyuki, Yasunaga, Masahiro, Matsumura, Yasuhiro
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2015
Aiheet:
Cancer Therapy
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024081/
https://ncbi.nlm.nih.gov/pubmed/25704403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.29492
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