Antitumor effect of antitissue factor antibody‐MMAE conjugate in human pancreatic tumor xenografts

Tissue factor (TF) triggers the extrinsic blood coagulation cascade and is highly expressed in various types of cancer. In this study, we investigated the antitumor effect of an antibody–drug conjugate (ADC) consisting of an anti‐TF monoclonal antibody and monomethyl auristatin E (MMAE). MMAE was co...

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Vydáno v:Int J Cancer
Hlavní autoři: Koga, Yoshikatsu, Manabe, Shino, Aihara, Yoshiyuki, Sato, Ryuta, Tsumura, Ryo, Iwafuji, Hikaru, Furuya, Fumiaki, Fuchigami, Hirobumi, Fujiwara, Yuki, Hisada, Yohei, Yamamoto, Yoshiyuki, Yasunaga, Masahiro, Matsumura, Yasuhiro
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2015
Témata:
Cancer Therapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024081/
https://ncbi.nlm.nih.gov/pubmed/25704403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.29492
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