Antitumor effect of antitissue factor antibody‐MMAE conjugate in human pancreatic tumor xenografts

Tissue factor (TF) triggers the extrinsic blood coagulation cascade and is highly expressed in various types of cancer. In this study, we investigated the antitumor effect of an antibody–drug conjugate (ADC) consisting of an anti‐TF monoclonal antibody and monomethyl auristatin E (MMAE). MMAE was co...

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Detalhes bibliográficos
Publicado no:Int J Cancer
Main Authors: Koga, Yoshikatsu, Manabe, Shino, Aihara, Yoshiyuki, Sato, Ryuta, Tsumura, Ryo, Iwafuji, Hikaru, Furuya, Fumiaki, Fuchigami, Hirobumi, Fujiwara, Yuki, Hisada, Yohei, Yamamoto, Yoshiyuki, Yasunaga, Masahiro, Matsumura, Yasuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Cancer Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024081/
https://ncbi.nlm.nih.gov/pubmed/25704403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.29492
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