ET-05 PRECLINICAL STUDY OF AN ANTI-HUMAN TISSUE FACTOR ANTIBODY-DRUG CONJUGATE IN A MALIGNANT GLIOMA XENOGRAFT MODEL

Whereas macromolecules such as antibody hardly extravasate from normal blood vessels compared with low molecular agents, macromolecules leak from tumor vasculature because of the enhanced permeability. As a result, macromolecules selectively accumulate at tumor sites. We apply this phenomenon, known...

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Publicado en:Neurooncol Adv
Main Authors: Takashima, Hiroki, Manabe, Shino, Tsuji, Atsushi, Saga, Tsuneo, Tsumura, Ryo, Anzai, Takahiro, Koga, Yoshikatsu, Yasunaga, Masahiro, Kuroda, Jun-Ichiro, Mukasa, Akitake, Matsumura, Yasuhiro
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
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Abstracts
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213193/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz039.039
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