ET-05 PRECLINICAL STUDY OF AN ANTI-HUMAN TISSUE FACTOR ANTIBODY-DRUG CONJUGATE IN A MALIGNANT GLIOMA XENOGRAFT MODEL

Whereas macromolecules such as antibody hardly extravasate from normal blood vessels compared with low molecular agents, macromolecules leak from tumor vasculature because of the enhanced permeability. As a result, macromolecules selectively accumulate at tumor sites. We apply this phenomenon, known...

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Publicat a:Neurooncol Adv
Autors principals: Takashima, Hiroki, Manabe, Shino, Tsuji, Atsushi, Saga, Tsuneo, Tsumura, Ryo, Anzai, Takahiro, Koga, Yoshikatsu, Yasunaga, Masahiro, Kuroda, Jun-Ichiro, Mukasa, Akitake, Matsumura, Yasuhiro
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
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Abstracts
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213193/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz039.039
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