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PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions

Mammalian prions are unusual infectious agents, as they are thought to consist solely of aggregates of misfolded prion protein (PrP). Generation of synthetic prions, composed of recombinant PrP (recPrP) refolded into fibrils, has been utilised to address whether PrP aggregates are, indeed, infectiou...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Barron, Rona M., King, Declan, Jeffrey, Martin, McGovern, Gillian, Agarwal, Sonya, Gill, Andrew C., Piccardo, Pedro
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023723/
https://ncbi.nlm.nih.gov/pubmed/27376534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1594-5
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