Recovery of Small Infectious PrP(res) Aggregates from Prion-infected Cultured Cells

Prion diseases are characterized by deposits of abnormal conformers of the PrP protein. Although large aggregates of proteinase K-resistant PrP (PrP(res)) are infectious, the precise relationships between aggregation state and infectivity remain to be established. In this study, we have fractionated...

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Bibliographic Details
Main Authors: Anaya, Zaira E. Arellano, Savistchenko, Jimmy, Massonneau, Véronique, Lacroux, Caroline, Andréoletti, Olivier, Vilette, Didier
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048700/
https://ncbi.nlm.nih.gov/pubmed/21212268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.165233
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