PrP Expression Level and Sensitivity to Prion Infection

Mice overexpressing the prion protein (PrP) sequence from various host species are widely used for measuring infectious titers in prion disease. However, the impact that the transgene expression level might have on the susceptibility to infection raises some concerns about the final biological relev...

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Autors principals: Douet, Jean-Yves, Lacroux, Caroline, Corbière, Fabien, Litaise, Claire, Simmons, Hugh, Lugan, Séverine, Costes, Pierrette, Cassard, Hervé, Weisbecker, Jean-Louis, Schelcher, François, Andreoletti, Olivier
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Prions
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019126/
https://ncbi.nlm.nih.gov/pubmed/24574409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00369-14
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