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PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility

PERK (EIF2AK3) is an ER-resident eIF2α kinase required for memory flexibility and metabotropic glutamate receptor-dependent long-term depression, processes known to be dependent on new protein synthesis. Here we investigated PERK’s role in working memory, a cognitive ability that is independent of n...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Zhu, Siying, Henninger, Keely, McGrath, Barbara C., Cavener, Douglas R.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023101/
https://ncbi.nlm.nih.gov/pubmed/27627766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162766
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