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Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions.

Insulin synthesis and cell proliferation are under tight regulation in pancreatic β-cells to maintain glucose homeostasis. Dysfunction in either aspect leads to development of diabetes. PERK (EIF2AK3) loss of function mutations in humans and mice exhibit permanent neonatal diabetes that is character...

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Detalhes bibliográficos
Main Authors: Rong Wang, Elyse E Munoz, Siying Zhu, Barbara C McGrath, Douglas R Cavener
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2014-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC4051701?pdf=render
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