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PERK in beta cell biology and insulin biogenesis
PERK (EIF2AK3) was originally discovered as a major component of the Unfolded Protein Response (UPR). PERK deficiency results in permanent neonatal diabetes, which was initially thought to be caused by a failure to regulate ER stress in insulin-secreting beta cells, culminating in beta cell death. H...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2991375/ https://ncbi.nlm.nih.gov/pubmed/20850340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tem.2010.08.005 |
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