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PERK in beta cell biology and insulin biogenesis

PERK (EIF2AK3) was originally discovered as a major component of the Unfolded Protein Response (UPR). PERK deficiency results in permanent neonatal diabetes, which was initially thought to be caused by a failure to regulate ER stress in insulin-secreting beta cells, culminating in beta cell death. H...

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Detalhes bibliográficos
Main Authors: Cavener, Douglas R., Gupta, Sounak, McGrath, Barbara C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991375/
https://ncbi.nlm.nih.gov/pubmed/20850340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tem.2010.08.005
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