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PERK in beta cell biology and insulin biogenesis

PERK (EIF2AK3) was originally discovered as a major component of the Unfolded Protein Response (UPR). PERK deficiency results in permanent neonatal diabetes, which was initially thought to be caused by a failure to regulate ER stress in insulin-secreting beta cells, culminating in beta cell death. H...

詳細記述

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書誌詳細
主要な著者: Cavener, Douglas R., Gupta, Sounak, McGrath, Barbara C.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991375/
https://ncbi.nlm.nih.gov/pubmed/20850340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tem.2010.08.005
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