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PERK Regulates the Proliferation and Development of Insulin-Secreting Beta-Cell Tumors in the Endocrine Pancreas of Mice

BACKGROUND: PERK eIF2α kinase is required for the proliferation of the insulin-secreting beta- cells as well as insulin synthesis and secretion. In addition, PERK signaling has been found to be an important factor in determining growth and angiogenesis of specific types of tumors, and was attributed...

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Détails bibliographiques
Auteurs principaux: Gupta, Sounak, McGrath, Barbara, Cavener, Douglas R.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776514/
https://ncbi.nlm.nih.gov/pubmed/19956728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008008
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