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Perk Gene Dosage Regulates Glucose Homeostasis by Modulating Pancreatic β-Cell Functions
BACKGROUND: Insulin synthesis and cell proliferation are under tight regulation in pancreatic β-cells to maintain glucose homeostasis. Dysfunction in either aspect leads to development of diabetes. PERK (EIF2AK3) loss of function mutations in humans and mice exhibit permanent neonatal diabetes that...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4051701/ https://ncbi.nlm.nih.gov/pubmed/24915520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099684 |
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