Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype

Our previous studies showed that adult (8 month) mice lacking CuZn-superoxide dismutase (CuZnSOD, Sod1KO mice) have neuromuscular changes resulting in dramatic accelerated muscle atrophy and weakness that mimics age-related sarcopenia. We have further shown that loss of CuZnSOD targeted to skeletal...

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Podrobná bibliografie
Vydáno v:Redox Biol
Hlavní autoři: Sataranatarajan, Kavithalakshmi, Qaisar, Rizwan, Davis, Carol, Sakellariou, Giorgos K., Vasilaki, Aphrodite, Zhang, Yiqiang, Liu, Yuhong, Bhaskaran, Shylesh, McArdle, Anne, Jackson, Malcolm, Brooks, Susan V., Richardson, Arlan, Van Remmen, Holly
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5022075/
https://ncbi.nlm.nih.gov/pubmed/25917273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2015.04.005
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