Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice

Deletion of copper-zinc superoxide dismutase (CuZnSOD) in Sod1(−/−) mice leads to accelerated loss of muscle mass and force during aging, but the losses do not occur with muscle-specific deletion of CuZnSOD. To determine the role of motor neurons in the muscle decline, we generated transgenic Sod1(−...

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Hauptverfasser: Sakellariou, Giorgos K., Davis, Carol S., Shi, Yun, Ivannikov, Maxim V., Zhang, Yiqiang, Vasilaki, Aphrodite, Macleod, Gregory T., Richardson, Arlan, Van Remmen, Holly, Jackson, Malcolm J., McArdle, Anne, Brooks, Susan V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2014
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963022/
https://ncbi.nlm.nih.gov/pubmed/24378874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-240390
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