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CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice

We have previously shown that deletion of CuZnSOD in mice (Sod1(−/−) mice) leads to accelerated loss of muscle mass and contractile force during aging. To dissect the relative roles of skeletal muscle and motor neurons in this process, we used a Cre-Lox targeted approach to establish a skeletal musc...

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Main Authors: Zhang, Yiqiang, Davis, Carol, Sakellariou, George K., Shi, Yun, Kayani, Anna C., Pulliam, Daniel, Bhattacharya, Arunabh, Richardson, Arlan, Jackson, Malcolm J., McArdle, Anne, Brooks, Susan V., Van Remmen, Holly
Format: Artigo
Jezik:Inglês
Izdano: Federation of American Societies for Experimental Biology 2013
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752542/
https://ncbi.nlm.nih.gov/pubmed/23729587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-228130
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