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Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice

Mice Jacking Cu/Zn-superoxide dismutase (Sod1(−/−) or sod1KO mice) show high levels of oxidative stress/damage and a 30% decrease in lifespan. The Sod1KO mice also show many phenotypes of accelerated aging with the loss of muscle mass and function being one of the most prominent aging phenotypes. Us...

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Bibliografiske detaljer
Udgivet i:Free Radic Biol Med
Main Authors: Deepa, Sathyaseelan S., Van Remmen, Holly, Brooks, Susan V., Faulkner, John A., Larkin, Lisa, McArdle, Anne, Jackson, Malcolm J., Vasilaki, Aphrodite, Richardson, Arlan
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6405207/
https://ncbi.nlm.nih.gov/pubmed/30670156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2018.06.032
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