Editing T cell specificity towards leukemia by zinc-finger nucleases and lentiviral gene transfer

The transfer of high-avidity T-cell receptor (TCR) genes isolated from rare tumor-specific lymphocytes into polyclonal T cells is an attractive cancer immunotherapy strategy. However, TCR gene transfer results in competition for surface expression and inappropriate pairing between the exogenous and...

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Publicado en:Nat Med
Autores principales: Provasi, Elena, Genovese, Pietro, Lombardo, Angelo, Magnani, Zulma, Liu, Pei-Qi, Reik, Andreas, Chu, Victoria, Paschon, David E., Zhang, Lei, Kuball, Jurgen, Camisa, Barbara, Bondanza, Attilio, Casorati, Giulia, Ponzoni, Maurilio, Ciceri, Fabio, Bordignon, Claudio, Greenberg, Philip D., Holmes, Michael C., Gregory, Philip D., Naldini, Luigi, Bonini, Chiara
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019824/
https://ncbi.nlm.nih.gov/pubmed/22466705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2700
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