Editing T cell specificity towards leukemia by zinc-finger nucleases and lentiviral gene transfer

The transfer of high-avidity T-cell receptor (TCR) genes isolated from rare tumor-specific lymphocytes into polyclonal T cells is an attractive cancer immunotherapy strategy. However, TCR gene transfer results in competition for surface expression and inappropriate pairing between the exogenous and...

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Detaylı Bibliyografya
Yayımlandı:Nat Med
Asıl Yazarlar: Provasi, Elena, Genovese, Pietro, Lombardo, Angelo, Magnani, Zulma, Liu, Pei-Qi, Reik, Andreas, Chu, Victoria, Paschon, David E., Zhang, Lei, Kuball, Jurgen, Camisa, Barbara, Bondanza, Attilio, Casorati, Giulia, Ponzoni, Maurilio, Ciceri, Fabio, Bordignon, Claudio, Greenberg, Philip D., Holmes, Michael C., Gregory, Philip D., Naldini, Luigi, Bonini, Chiara
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019824/
https://ncbi.nlm.nih.gov/pubmed/22466705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2700
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