Editing T cell specificity towards leukemia by zinc-finger nucleases and lentiviral gene transfer

The transfer of high-avidity T-cell receptor (TCR) genes isolated from rare tumor-specific lymphocytes into polyclonal T cells is an attractive cancer immunotherapy strategy. However, TCR gene transfer results in competition for surface expression and inappropriate pairing between the exogenous and...

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Publicat a:Nat Med
Autors principals: Provasi, Elena, Genovese, Pietro, Lombardo, Angelo, Magnani, Zulma, Liu, Pei-Qi, Reik, Andreas, Chu, Victoria, Paschon, David E., Zhang, Lei, Kuball, Jurgen, Camisa, Barbara, Bondanza, Attilio, Casorati, Giulia, Ponzoni, Maurilio, Ciceri, Fabio, Bordignon, Claudio, Greenberg, Philip D., Holmes, Michael C., Gregory, Philip D., Naldini, Luigi, Bonini, Chiara
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019824/
https://ncbi.nlm.nih.gov/pubmed/22466705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2700
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