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Editing T cell specificity towards leukemia by zinc-finger nucleases and lentiviral gene transfer
The transfer of high-avidity T-cell receptor (TCR) genes isolated from rare tumor-specific lymphocytes into polyclonal T cells is an attractive cancer immunotherapy strategy. However, TCR gene transfer results in competition for surface expression and inappropriate pairing between the exogenous and...
Shranjeno v:
| izdano v: | Nat Med |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5019824/ https://ncbi.nlm.nih.gov/pubmed/22466705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2700 |
| Oznake: |
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