Editing T cell specificity towards leukemia by zinc-finger nucleases and lentiviral gene transfer

The transfer of high-avidity T-cell receptor (TCR) genes isolated from rare tumor-specific lymphocytes into polyclonal T cells is an attractive cancer immunotherapy strategy. However, TCR gene transfer results in competition for surface expression and inappropriate pairing between the exogenous and...

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Bibliografske podrobnosti
izdano v:Nat Med
Main Authors: Provasi, Elena, Genovese, Pietro, Lombardo, Angelo, Magnani, Zulma, Liu, Pei-Qi, Reik, Andreas, Chu, Victoria, Paschon, David E., Zhang, Lei, Kuball, Jurgen, Camisa, Barbara, Bondanza, Attilio, Casorati, Giulia, Ponzoni, Maurilio, Ciceri, Fabio, Bordignon, Claudio, Greenberg, Philip D., Holmes, Michael C., Gregory, Philip D., Naldini, Luigi, Bonini, Chiara
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019824/
https://ncbi.nlm.nih.gov/pubmed/22466705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2700
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