Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells

The use of retroviral vectors in gene therapy has raised safety concerns for the genotoxic risk associated with their uncontrolled insertion into the human genome. We have analyzed the consequences of retroviral transduction in T cells from leukemic patients treated with allogeneic stem cell transpl...

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Detalhes bibliográficos
Main Authors: Recchia, Alessandra, Bonini, Chiara, Magnani, Zulma, Urbinati, Fabrizia, Sartori, Daniela, Muraro, Sara, Tagliafico, Enrico, Bondanza, Attilio, Stanghellini, Maria Teresa Lupo, Bernardi, Massimo, Pescarollo, Alessandra, Ciceri, Fabio, Bordignon, Claudio, Mavilio, Fulvio
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360534/
https://ncbi.nlm.nih.gov/pubmed/16432223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507496103
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