Transcription Factor Binding Sites Are Genetic Determinants of Retroviral Integration in the Human Genome

Gamma-retroviruses and lentiviruses integrate non-randomly in mammalian genomes, with specific preferences for active chromatin, promoters and regulatory regions. Gene transfer vectors derived from gamma-retroviruses target at high frequency genes involved in the control of growth, development and d...

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Detalhes bibliográficos
Main Authors: Felice, Barbara, Cattoglio, Claudia, Cittaro, Davide, Testa, Anna, Miccio, Annarita, Ferrari, Giuliana, Luzi, Lucilla, Recchia, Alessandra, Mavilio, Fulvio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2642719/
https://ncbi.nlm.nih.gov/pubmed/19238208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004571
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