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The GATA1-HS2 Enhancer Allows Persistent and Position-Independent Expression of a β-globin Transgene
Gene therapy of genetic diseases requires persistent and position-independent expression of a therapeutic transgene. Transcriptional enhancers binding chromatin-remodeling and modifying complexes may play a role in shielding transgenes from repressive chromatin effects. We tested the activity of the...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3229501/ https://ncbi.nlm.nih.gov/pubmed/22164220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027955 |
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